Number Of Drugs You Shouldn’t Mix With Grapefruit Climbs From 17 To 43

If you’re one of those people who don’t really read all those boring warning labels on your medications because come on, you know how to take a pill (guilty), well you might want to pay attention, especially if you like grapefruit. Researchers say taking certain medications with the fruit can cause a person to overdose accidentally.

It’s all due to how grapefruit stops medicines from being broken down in the intestines and the liver, say researchers in a paper published in the Canadian Medical Association Journal, cited by the BBC. At first the number of meds linked to this odd-grapefruit reaction was at around 17, but now experts say there are a whopping 43 drugs that need to be kept separate from the fruit.

Researchers say the medications range from those to treat blood pressure, cancer and cholesterol-lowering statins as well as those taken to suppress the immune system after an organ transplant.

It all boils down to chemicals in the grapefruit which disables the enzyme the body uses to breaks drugs down. That means more of the drug than you need goes into your body.

From the BBC:

Three times the levels of one blood pressure drug, felodipine, was reported after patients had a glass of grapefruit juice compared with a glass of water.

The side effects are varied depending on the drug, but include stomach bleeds, altered heart beat, kidney damage and sudden death.

A bit scary, to go from a regular, helpful medication to a dastardly drug in just a glass of juice, but one of the researchers says it’s no laughing matter.

“One tablet with a glass of grapefruit juice can be like taking five or 10 tablets with a glass of water and people say I don’t believe it, but I can show you that scientifically it is sound,” a researcher told the BBC. “So you can unintentionally go from a therapeutic level to a toxic level just by consuming grapefruit juice.”

Researchers are worried there isn’t enough attention being paid to this problem, and advise healthcare professionas to make sure their patients are totally aware of the potential health risks. It isn’t just grapefruit, either — Seville oranges and limes can also mess up meds.

When in doubt, read your drug labels and stick to swilling water with your pills.

Grapefruit and pills mix warning [BBC]